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At the PRP Arthritis Clinic of Toronto, we utilize the most advanced, study proven therapy techniques.

PRP therapy has rapidly grown in therapy in the past few years.  The beneficial effects of PRP are documented in scholarly journals across the world.

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OUR TEAM IS A collection of experienced physiotherapists and orthopaedic surgeons.

OUR SERVICES

  • Physiotherapy
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TESTIMONIALS


In addition to PRP Therapy, we offer a range of other treatment options...


Our team of experts are experienced in the treatment of a wide variety of orthopaedic and sports-related injuries.  Let us help you.

The Efficacy of Platelet-Rich Plasma in the Treatment of Symptomatic Knee Osteoarthritis: A Systematic Review With Quantitative SynthesisType your paragraph here


Amir Khoshbin, M.D., Timothy Leroux, M.D., David Wasserstein, M.D., M.Sc., F.R.C.S.C., Paul Marks, M.D., F.R.C.S.C., John Theodoropoulos, M.D., M.Sc., F.R.C.S.C., Darrell Ogilvie-Harris, M.D., F.R.C.S.C., Rajiv Gandhi, M.D., F.R.C.S.C., Kirat Takhar, B.Kin., Grant Lum, M.D., Jaskarndip Chahal, M.D., M.Sc., F.R.C.S.C.


Purpose

The purpose of this systematic review was to synthesize the available Level I and Level II literature on platelet-rich plasma (PRP) as a therapeutic intervention in the management of symptomatic knee osteoarthritis (OA).

Methods

A systematic review of Medline, Embase, Cochrane Central Register of Controlled Trials, PubMed, andwww.clinicaltrials.gov was performed to identify all randomized controlled trials and prospective cohort studies that evaluated the clinical efficacy of PRP versus a control injection for knee OA. A random-effects model was used to evaluate the therapeutic effect of PRP at 24 weeks by use of validated outcome measures (Western Ontario and McMaster Universities Arthritis Index, visual analog scale for pain, International Knee Documentation Committee Subjective Knee Evaluation Form, and overall patient satisfaction).

Results

Six Level I and II studies satisfied our inclusion criteria (4 randomized controlled trials and 2 prospective nonrandomized studies). A total of 577 patients were included, with 264 patients (45.8%) in the treatment group (PRP) and 313 patients (54.2%) in the control group (hyaluronic acid [HA] or normal saline solution [NS]). The mean age of patients receiving PRP was 56.1 years (51.5% male patients) compared with 57.1 years (49.5% male patients) for the group receiving HA or NS. Pooled results using the Western Ontario and McMaster Universities Arthritis Index scale (4 studies) showed that PRP was significantly better than HA or NS injections (mean difference, −18.0 [95% confidence interval, −28.8 to −8.3]; P< .001). Similarly, the International Knee Documentation Committee scores (3 studies) favored PRP as a treatment modality (mean difference, 7.9 [95% confidence interval, 3.7 to 12.1]; P < .001). There was no difference in the pooled results for visual analog scale score or overall patient satisfaction. Adverse events occurred more frequently in patients treated with PRP than in those treated with HA/placebo (8.4% v 3.8%, P = .002).

Conclusions

As compared with HA or NS injection, multiple sequential intra-articular PRP injections may have beneficial effects in the treatment of adult patients with mild to moderate knee OA at approximately 6 months. There appears to be an increased incidence of nonspecific adverse events among patients treated with PRP.

Level of evidence

Level II, systematic review of Level I and II studies.




What is Platelet-Rich Plasma (PRP)?

Blood is mainly a liquid, but contains small solid components. These components are suspended in a liquid called plasma, and are comprised of red cells, white cells and platelets. 

Typically a blood specimen contains 93% red cells, 1% white cells and 6% platelets. Each component plays an important role for the human body to function. Red blood cells serve to carry oxygen from the lungs and to deliver it to other cells throughout the body, while also removing carbon dioxide. White blood cells fight infection, kill germs, and carry off dead blood cells.

Platelets are responsible for the construction of new connective tissue, and contain proteins called growth factors that are very important in the healing of injuries. Simply put, PRP is plasma that has been modified to have a higher concentration of platelets.